Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) (Middle Region) Peptide
RPE65
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5512452
Quick Overview for Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) (Middle Region) Peptide (ABIN5512452)
Target
RPE65
(Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- LFKFLSSWSL WGANYMDCFE SNETMGVWLH IADKKRKKYL NNKYRTSPFN
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-RPE65 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))
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Background
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This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa.
Alias Symbols: RPE65,
Protein Size: 533 -
Gene ID
- 6121
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NCBI Accession
- NP_000320
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UniProt
- Q16518
Target
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