AU RNA Binding Protein/enoyl-CoA Hydratase (AUH) (N-Term) Peptide
AUH
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5512748
Quick Overview for AU RNA Binding Protein/enoyl-CoA Hydratase (AUH) (N-Term) Peptide (ABIN5512748)
Target
AUH
(AU RNA Binding Protein/enoyl-CoA Hydratase (AUH))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- IWAQGWVPAA GGPAPKRGYS SEMKTEDELR VRHLEEENRG IVVLGINRAY
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-AUH Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- AUH (AU RNA Binding Protein/enoyl-CoA Hydratase (AUH))
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Background
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The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92 % identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40- kDa precursor protein which is subsequently processed to a 32- kDa mature form.
Alias Symbols: AUH,
Protein Size: 339 -
Gene ID
- 549
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UniProt
- Q13825
Target
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