Fms-Related tyrosine Kinase 3 (FLT3) (N-Term) Peptide
FLT3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5512790
$160.46
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100 μg
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United States
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Quick Overview for Fms-Related tyrosine Kinase 3 (FLT3) (N-Term) Peptide (ABIN5512790)
Target
FLT3
(Fms-Related tyrosine Kinase 3 (FLT3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- Synthetic peptide located within the following region: < a href='http://www.ncbi.nlm.nih.gov/blast/Blast.cgi?PROGRAM=blastp&CLIENT=web&SERVICE=plain&PAGE=Proteins&CMD=Put&DATABASE=nr&CDD_SEARCH=1&AUTO_FORMAT=Semi-auto&SHOW_OVERVIEW=on&SHOW_LINKOUT=on&GET_S
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-FLT3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
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Background
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This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Alias Symbols: FLK2, STK1, CD135, FLK-2
Protein Size: 952 -
Gene ID
- 2322
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NCBI Accession
- NM_004119, NP_004110
Target
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