Fms-Related tyrosine Kinase 3 (FLT3) (N-Term) Peptide
FLT3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all FLT3 products
- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- Synthetic peptide located within the following region: < a href='http://www.ncbi.nlm.nih.gov/blast/Blast.cgi?PROGRAM=blastp&CLIENT=web&SERVICE=plain&PAGE=Proteins&CMD=Put&DATABASE=nr&CDD_SEARCH=1&AUTO_FORMAT=Semi-auto&SHOW_OVERVIEW=on&SHOW_LINKOUT=on&GET_S
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-FLT3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
- Synonyms
- FLT3 Peptide, B230315G04 Peptide, CD135 Peptide, Flk-2 Peptide, Flk2 Peptide, Flt-3 Peptide, Ly72 Peptide, wmfl Peptide, FLK-2 Peptide, FLK2 Peptide, STK1 Peptide, fms related tyrosine kinase 3 Peptide, FMS-like tyrosine kinase 3 Peptide, fms-related tyrosine kinase 3 Peptide, FLT3 Peptide, Flt3 Peptide
- Background
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This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Alias Symbols: FLK2, STK1, CD135, FLK-2
Protein Size: 952 - Gene ID
- 2322
- NCBI Accession
- NM_004119, NP_004110
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