BR serine/threonine Kinase 2 (BRSK2) (Middle Region) Peptide
BRSK2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5513347
Quick Overview for BR serine/threonine Kinase 2 (BRSK2) (Middle Region) Peptide (ABIN5513347)
Target
BRSK2
(BR serine/threonine Kinase 2 (BRSK2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- EEENQEKMIY FLLLDRKERY PSQEDEDLPP RNEIDPPRKR VDSPMLNRHG
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-BRSK2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- BRSK2 (BR serine/threonine Kinase 2 (BRSK2))
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Background
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BRSK2 is a serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. It phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. It also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. It plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. It plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 is phosphorylated at Thr-174 can inhibit insulin secretion, BRSK2 is phosphorylated at Thr-260 can promote insulin secretion. It regulates reorganization of the actin cytoskeleton. It may play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.
Alias Symbols: BRSK2,C11orf7,PEN11B,SADA,STK29,HUSSY-12,
Protein Size: 766 -
Gene ID
- 9024
Target
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