Minichromosome Maintenance Complex Component 3 (MCM3) (C-Term) Peptide
MCM3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5513410
Quick Overview for Minichromosome Maintenance Complex Component 3 (MCM3) (C-Term) Peptide (ABIN5513410)
Target
MCM3
(Minichromosome Maintenance Complex Component 3 (MCM3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- ETEDEEEKSQ EDQEQKRKRR KTRQPDAKDG DSYDPYDFSD TEEEMPQVHT
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- MCM3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))
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Background
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The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HCC5, P1.h, RLFB, P1-MCM3
Protein Size: 808 -
Gene ID
- 4172
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NCBI Accession
- NM_001270472, NP_001257401
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UniProt
- P25205
Target
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