Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12) (Middle Region) Peptide
MMP12
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MMP12 products
- MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- RGIQSLYGDP KENQRLPNPD NSEPALCDPN LSFDAVTTVG NKIFFFKDRF
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-MMP12 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))
- Background
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This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11.
Alias Symbols: ME, HME, MME, MMP-12
Protein Size: 470 - Gene ID
- 4321
- NCBI Accession
- NM_002426, NP_002417
- UniProt
- P39900
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