Murine Retrovirus Integration Site 1 Homolog (MRVI1) (N-Term) Peptide
MRVI1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5513424
$160.46
Plus shipping costs $50.00
100 μg
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United States
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Quick Overview for Murine Retrovirus Integration Site 1 Homolog (MRVI1) (N-Term) Peptide (ABIN5513424)
Target
MRVI1
(Murine Retrovirus Integration Site 1 Homolog (MRVI1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- LVNDQLPDIS ISEEDKKKNL ALLEEAKLVS ERFLTRRGRK SRSSPGDSPS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-MRVI1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))
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Background
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This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
Protein Size: 803 -
Gene ID
- 10335
Target
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