Transmembrane Protease, serine 2 (TMPRSS2) (Middle Region) Peptide
TMPRSS2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5513593
Quick Overview for Transmembrane Protease, serine 2 (TMPRSS2) (Middle Region) Peptide (ABIN5513593)
Target
TMPRSS2
(Transmembrane Protease, serine 2 (TMPRSS2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- SFMFYGAGYQ VEKVISHPNY DSKTKNNDIA LMKLQKPLTF NDLVKPVCLP
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- TMPRSS2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))
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Background
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This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: PP9284, PRSS10
Protein Size: 492 -
Gene ID
- 7113
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NCBI Accession
- NM_001135099, NP_001128571
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UniProt
- O15393
Target
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