Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) (N-Term) Peptide
WAS
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5513614
$160.46
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100 μg
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Quick Overview for Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) (N-Term) Peptide (ABIN5513614)
Target
WASP (WAS)
(Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- IQKRNQRQSG DRRQLPPPPT PANEERRGGL PPLPLHPGGD QGGPPVGPLS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-WASP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))
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Background
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The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
Alias Symbols: WAS,IMD2,
Protein Size: 502 -
Gene ID
- 7454
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NCBI Accession
- NP_000368
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UniProt
- P42768
Target
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