Single-Minded Homolog 2 (SIM2) (Middle Region) Peptide
SIM2
Reactivity: Human
Host: Synthetic
WB
Catalog No. ABIN5518205
Quick Overview for Single-Minded Homolog 2 (SIM2) (Middle Region) Peptide (ABIN5518205)
Target
SIM2
(Single-Minded Homolog 2 (SIM2))
Origin
Human
Source
Synthetic
Application
Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- SWRTALSTSQ ETRKLVKPKN TKMKTKLRTN PYPPQQYSSF QMDKLECGQL
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SIM2 (Single-Minded Homolog 2 (SIM2))
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Background
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This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.
Alias Symbols: SIM, bHLHe15, HMC13F06, HMC29C01
Protein Size: 167 -
Gene ID
- 6493
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NCBI Accession
- NM_005069, NP_005060
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UniProt
- Q14190
Target
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