Hepcidin Antimicrobial Peptide (HAMP) (Middle Region) Peptide
Quick Overview for Hepcidin Antimicrobial Peptide (HAMP) (Middle Region) Peptide (ABIN5518385)
Target
Origin
Source
Application
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Protein Region
- Middle Region
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Sequence
- WAACLLLLLL LASLTSGSVF PQQTGQLAEL QPQDRAGARA SWMPMFQRRR
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Hepcidin Antimicrobial Peptide (HAMP) peptide (Ovalbumin)
HAMP Reactivity: Human Host: Synthetic WB, Imm, SDS
Hepcidin Antimicrobial Peptide (HAMP) peptide (Ovalbumin)HAMP Reactivity: Cow Host: Synthetic WB, Imm, SDS
Hepcidin Antimicrobial Peptide (HAMP) peptide (Ovalbumin)HAMP Reactivity: Human Host: Synthetic WB, Imm, SDS
Hepcidin Antimicrobial Peptide (HAMP) peptide (Ovalbumin)HAMP Reactivity: Cow Host: Synthetic WB, Imm, SDS
Hepcidin Antimicrobial Peptide (HAMP) peptide (Ovalbumin)HAMP Reactivity: Human Host: Synthetic WB, Imm, SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))
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Background
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The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
Alias Symbols: HEPC, PLTR, HFE2B, LEAP1
Protein Size: 113 -
Gene ID
- 57817
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NCBI Accession
- NM_021175, NP_066998
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UniProt
- P81172
Target
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