Unc-13 Homolog B (UNC13B) (Middle Region) Peptide
UNC13B
Reactivity: Human
Host: Synthetic
WB
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- Target See all UNC13B products
- UNC13B (Unc-13 Homolog B (UNC13B))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Western Blotting (WB)
- Sequence
- SYDLDYPERR AISPTSSSRY GSSCNVSQGS SQLSELDQYH EQDDDHRETD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- UNC13B (Unc-13 Homolog B (UNC13B))
- Background
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This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
Alias Symbols: UNC13, MUNC13, Unc13h2
Protein Size: 1591 - Gene ID
- 10497
- NCBI Accession
- NM_006377, NP_006368
- UniProt
- O14795
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