Myelin Protein Zero (MPZ) (Middle Region) Peptide
MPZ
Reactivity: Human
Host: Synthetic
WB
Catalog No. ABIN5518460
Quick Overview for Myelin Protein Zero (MPZ) (Middle Region) Peptide (ABIN5518460)
Target
MPZ
(Myelin Protein Zero (MPZ))
Origin
Human
Source
Synthetic
Application
Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- AALQRRLSAM EKGKLHKPGK DASKRGRQTP VLYAMLDHSR STKAVSEKKA
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Myelin Protein Zero (MPZ) peptide
MPZ Reactivity: Human, Rat, Mouse, Dog Host: Synthetic BP, Imm
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MPZ (Myelin Protein Zero (MPZ))
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Background
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This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.
Alias Symbols: P0, CHM, DSS, MPP, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, HMSNIB
Protein Size: 248 -
Gene ID
- 4359
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NCBI Accession
- NM_000530, NP_000521
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UniProt
- P25189
Target
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