Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (Middle Region) Peptide
MAPKAPK5
Reactivity: Human
Host: Synthetic
WB
Catalog No. ABIN5518501
Quick Overview for Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) (Middle Region) Peptide (ABIN5518501)
Target
MAPKAP Kinase 5 (MAPKAPK5)
(Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5))
Origin
Human
Source
Synthetic
Application
Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- TPYTYNKSCD LWSLGVIIYV MLCGYPPFYS KHHSRTIPKD MRRKIMTGSF
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MAPKAP Kinase 5 (MAPKAPK5) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5))
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Background
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The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alias Symbols: MK5, MK-5, PRAK, MAPKAP-K5
Protein Size: 473 -
Gene ID
- 8550
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NCBI Accession
- NM_003668, NP_003659
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UniProt
- Q8IW41
Target
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