Scavenger Receptor Class B, Member 2 (SCARB2) (Middle Region) Peptide
SCARB2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5671489
Quick Overview for Scavenger Receptor Class B, Member 2 (SCARB2) (Middle Region) Peptide (ABIN5671489)
Target
SCARB2
(Scavenger Receptor Class B, Member 2 (SCARB2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- EEILRGETPR VEEVGPYTYR ELRNKANIQF GDNGTTISAV SNKAYVFERD
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- SCARB2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SCARB2 (Scavenger Receptor Class B, Member 2 (SCARB2))
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Background
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The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: AMRF, EPM4, LGP85, CD36L2, HLGP85, LIMP-2, LIMPII, SR-BII
Protein Size: 478 -
Gene ID
- 950
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NCBI Accession
- NM_001204255, NP_001191184
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UniProt
- Q14108
Target
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