Endothelin 3 (EDN3) (Middle Region) Peptide
EDN3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5671568
Quick Overview for Endothelin 3 (EDN3) (Middle Region) Peptide (ABIN5671568)
Target
Endothelin 3 (EDN3)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- TQTLDVSSNS RTAEKTDKEE EGKVEVKDQQ SKQALDLHHP KLMPGSGLAL
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- EDN3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Endothelin 3 (EDN3)
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Background
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The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: ET3, ET-3, WS4B, HSCR4, PPET3
Protein Size: 219 -
Gene ID
- 1908
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NCBI Accession
- NM_001302455, NP_001289384
Target
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