Methyl-CpG Binding Domain Protein 2 (MBD2) (Middle Region) Peptide
MBD2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MBD2 products
- MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ARYLGNTVDL SSFDFRTGKM MPSKLQKNKQ RLRNDPLNQN KGKPDLNTTL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- MBD2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))
- Background
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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: DMTase, NY-CO-41
Protein Size: 302 - Gene ID
- 8932
- NCBI Accession
- NM_003927, NP_003918
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