RAB8A, Member RAS Oncogene Family (RAB8A) (Middle Region) Peptide
RAB8A
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5671709
Quick Overview for RAB8A, Member RAS Oncogene Family (RAB8A) (Middle Region) Peptide (ABIN5671709)
Target
RAB8A
(RAB8A, Member RAS Oncogene Family (RAB8A))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- VNDKRQVSKE RGEKLALDYG IKFMETSAKA NINVENAFFT LARDIKAKMD
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- RAB8A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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RAB8A, Member RAS Oncogene Family (RAB8A) peptide
RAB8A Reactivity: Human, Cow, Dog Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))
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Background
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The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97 % , 96 %, and 51 % similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.
Alias Symbols: MEL, RAB8
Protein Size: 207 -
Gene ID
- 4218
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NCBI Accession
- NM_005370, NP_005361
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UniProt
- P61006
Target
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