Prune Homolog 2 (PRUNE2) (C-Term) Peptide
PRUNE2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5671799
Quick Overview for Prune Homolog 2 (PRUNE2) (C-Term) Peptide (ABIN5671799)
Target
PRUNE2
(Prune Homolog 2 (PRUNE2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- LNDTHPRRIK LTAPNINLSL DQSEGSILSD DNLDSPDEID INVDELDTPD
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- PRUNE2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PRUNE2 (Prune Homolog 2 (PRUNE2))
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Background
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The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants.
Alias Symbols: BMCC1, BNIPXL, C9orf65, KIAA0367
Protein Size: 352 -
Gene ID
- 158471
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NCBI Accession
- NM_001308047, NP_001294976
Target
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