Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) (N-Term) Peptide
PBX1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PBX1 products
- PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- RLMHSHAGVG MAGHPGLSQH LQDGAGGTEG EGGRKQDIGD ILQQIMTITD
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- PBX1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))
- Background
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This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1,19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein Size: 347 - Gene ID
- 5087
- NCBI Accession
- NM_001204963, NP_001191892
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