Arachidonate 5-Lipoxygenase (ALOX5) (Middle Region) Peptide
ALOX5
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5672355
Quick Overview for Arachidonate 5-Lipoxygenase (ALOX5) (Middle Region) Peptide (ABIN5672355)
Target
ALOX5
(Arachidonate 5-Lipoxygenase (ALOX5))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- RRKELETRQK QYRWMEWNPG FPLSIDAKCH KDLPRDIQFD SEKGVDFVLN
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- ALOX5 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Arachidonate 5-Lipoxygenase (ALOX5) peptide
ALOX5 Reactivity: Human, Rat, Dog, Mouse Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))
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Background
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This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: 5-LO, 5LPG, LOG5, 5-LOX
Protein Size: 484 -
Gene ID
- 240
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NCBI Accession
- NM_000698, NP_000689
Target
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