Fas (TNFRSF6)-Associated Via Death Domain (FADD) (Middle Region) Peptide
FADD
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5672776
Quick Overview for Fas (TNFRSF6)-Associated Via Death Domain (FADD) (Middle Region) Peptide (ABIN5672776)
Target
FADD
(Fas (TNFRSF6)-Associated Via Death Domain (FADD))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- LARQLKVSDT KIDSIEDRYP RNLTERVRES LRIWKNTEKE NATVAHLVGA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- FADD Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
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Background
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The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Alias Symbols: GIG3, MORT1
Protein Size: 208 -
Gene ID
- 8772
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NCBI Accession
- NM_003824, NP_003815
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UniProt
- Q13158
Target
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