Estrogen Receptor 1 (ESR1) (Middle Region) Peptide
ESR1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Estrogen Receptor alpha (ESR1) products
- Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- PQLSPFLQPH GQQVPYYLEN EPSGYTVREA GPPAFYRPNS DNRRQGGRER
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- ESR1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
- Background
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This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.
Alias Symbols: ER, ESR, Era, ESRA, ESTRR, NR3A1
Protein Size: 595 - Gene ID
- 2099
- NCBI Accession
- NM_000125, NP_000116
- UniProt
- P03372
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