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Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) (N-Term) Peptide

SPG20 Reactivity: Human Host: Synthetic BP, WB

Catalog No. ABIN5673676

Quick Overview for Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) (N-Term) Peptide (ABIN5673676)

Target

SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))

Origin

Human

Source

Synthetic

Application

Blocking Peptide (BP), Western Blotting (WB)

Protein Region

N-Term

Sequence

MEQEPQNGEP AEIKIIREAY KKAFLFVNKG LNTDELGQKE EAKNYYKQGI

Characteristics

This is a synthetic peptide designed for use in combination with anti- SPG20 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) peptide
SPG20 Host: Synthetic BP, Imm

Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) peptide
SPG20 Reactivity: Mammalian Host: Synthetic BP, WB, IHC

Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) (Middle Region) peptide
SPG20 Reactivity: Human Host: Synthetic BP, WB

Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) (Internal Region) peptide
SPG20 Reactivity: Human Host: Synthetic BP, BI

Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Lyophilized

Reconstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Storage

-20 °C

Storage Comment

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))

Background

This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).

Alias Symbols: SPARTIN, TAHCCP1

Protein Size: 666

Gene ID

23111

NCBI Accession

NM_001142294, NP_001135766

UniProt

Q8N0X7

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