Thioredoxin Reductase 1 (TXNRD1) (Middle Region) Peptide
TXNRD1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5673986
Quick Overview for Thioredoxin Reductase 1 (TXNRD1) (Middle Region) Peptide (ABIN5673986)
Target
TXNRD1
(Thioredoxin Reductase 1 (TXNRD1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- TGERPRYLGI PGDKEYCISS DDLFSLPYCP GKTLVVGASY VALECAGFLA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- TXNRD1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))
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Background
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The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis.
Alias Symbols: TR, TR1, TXNR, TRXR1, GRIM-12
Protein Size: 499 -
Gene ID
- 7296
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NCBI Accession
- NM_001093771, NP_001087240
Target
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