Catalog No. ABIN7582230
Quick Overview for Hm1a Toxin Peptide (ABIN7582230)
Target
Hm1a Toxin
Origin
Heteroscodra maculata
Source
Synthetic
Application
Blocking Peptide (BP)
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Peptide Type
- Synthetic
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Sequence
- ECRYLFGGCS STSDCCKHLS CRSDWKYCAW DGTFS-OH
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Specificity
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Toxin target: NaV1.1, KV2, KV4 channels,
Disulfide bonds between: Cys2-Cys16, Cys9-Cys21 and Cys15-Cys28 -
Purity
- ≥98 % (HPLC)
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Hm1a Toxin peptide
Reactivity: Heteroscodra maculata Host: Synthetic BP, FACS, FM, IF, LCI
Hm1a Toxin peptideReactivity: Heteroscodra maculata Host: Synthetic BP
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Application Notes
- Antigen Preadsorption Control: 50 nM - 1μM
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing, light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 μM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
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Buffer
- Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
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Storage
- 4 °C,-20 °C
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Storage Comment
- The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.,The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
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- Hm1a Toxin
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Background
- Delta-theraphotoxin-Hm1a, Delta-TRTX-Hm1a, Heteroscodratoxin-1, HmTx1, Kappa-theraphotoxin-Hm1a, Kappa-TRTX-Hm1a,Delta-theraphotoxin-Hm1a (Hm1a) is a peptide toxin originally isolated from Heteroscodra maculate tarantula venom. Initially described as a moderate-affinity KV4.1 blocker¹, later studies confirmed it primarily targets NaV1.1 voltage-gated sodium channels²,3. It interacts with extracellular loops connecting transmembrane segments 1-2 and 3-4 in domain IV voltage sensor of the channel to inhibit NaV1.1 fast inactivation2,3. Hm1a inhibits human NaV1.1 channel inactivation expressed in Xenopus oocytes with EC50 value of 38 ± 6 nM. Recent studies show Hm1a restores interneuron firing in Scn1a+/- mice, improving inhibition in Dravet Syndrome models⁴. Electrophysiology confirms it prolongs NaV1.1 activation with minimal effects on NaV1.2 and Na-1.6⁵,⁶. NaV1.1 channel is a therapeutic target for brain disorders, such as epilepsy, Alzheimer's disease, and autism. It also contributes to mechanical pain by regulating excitability in a specific subset of sensory neurons within the peripheral nervous system. Hm1a is a valuable tool for neuroscience and pharmacology research⁴-⁷.
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Molecular Weight
- 3997 Da
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UniProt
- P60992
Target
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