Kininogen 1 (KNG1) Peptide
KNG1
Reactivity: Human
Host: Synthetic
BP
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- Target See all KNG1 products
- KNG1 (Kininogen 1 (KNG1))
- Peptide Type
- Synthetic
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP)
- Purpose
- A Ligand of the B2 Bradykinin G-Protein Coupled Receptor
- Sequence
- RPPGFSPFR-OH
- Specificity
- Toxin target: B2 bradykinin receptor
- Characteristics
- A Ligand of the B2 Bradykinin G-Protein Coupled Receptor
- Purity
- ≥98 % (HPLC)
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Kininogen 1 (KNG1) peptide (BSA)
KNG1 Reactivity: Human Host: Synthetic WB, Imm, SDS
Kininogen 1 (KNG1) peptide (Ovalbumin)KNG1 Reactivity: Human Host: Synthetic WB, Imm, SDS
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- Application Notes
- Antigen Preadsorption Control: 30 - 300 nM
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing, light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 μM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
- Buffer
- Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
- Storage
- 4 °C,-20 °C
- Storage Comment
- The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.,The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
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- Target
- KNG1 (Kininogen 1 (KNG1))
- Background
- Kallidin I,Bradykinin is a potent effector peptide that binds the bradykinin receptors B2. Bradykinin reduces blood pressure and increases vascular permeability by inducing smooth muscle relaxation and blood vessel dilation1.Bradykinin is one the most potent known factors inducing pain substances that acts on afferent sensory neurons Bradykinin stimulates the synthesis of prostaglandins2 and is a major contributor to the innate inflammatory response3. Injection of Bradykinin into the skin produces all the inflammation basic signs4. Bradykinin has been implicated also in various shock syndromes5. Application of Bradykinin to the central nervous system appears to initiate events leading to neural tissue damage as well as long lasting disturbances affecting blood-brain barrier function6.
- Molecular Weight
- 1060.23 Da
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