Fumarate Hydratase (FH) (AA 44-510) Peptide
FH
Reactivity: Human
Host: Escherichia coli (E. coli)
SDS
1 image
Catalog No. ABIN935010
Quick Overview for Fumarate Hydratase (FH) (AA 44-510) Peptide (ABIN935010)
Target
FH
(Fumarate Hydratase (FH))
Origin
Human
Source
Escherichia coli (E. coli)
Application
SDS-PAGE (SDS)
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Peptide Type
- Recombinant
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Protein Region
- AA 44-510
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Sequence
- MASQNSFRIE YDTFGELKVP NDKYYGAQTV RSTMNFKIGG VTERMPTPVI KAFGILKRAA AEVNQDYGLD PKIANAIMKA ADEVAEGKLN DHFPLVVWQT GSGTQTNMNV NEVISNRAIE MLGGELGSKI PVHPNDHVNK SQSSNDTFPT AMHIAAAIEV HEVLLPGLQK LHDALDAKSK EFAQIIKIGR THTQDAVPLT LGQEFSGYVQ QVKYAMTRIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV AAKVAALTGL PFVTAPNKFE ALAAHDALVE LSGAMNTTAC SLMKIANDIR FLGSGPRSGL GELILPENEP GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA VTVGGSNGHF ELNVFKPMMI KNVLHSARLL GDASVSFTEN CVVGIQANTE RINKLMNESL MLVTALNPHI GYDKAAKIAK TAHKNGSTLK ETAIELGYLT AEQFDEWVKP KDMLGPK
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Characteristics
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Purified recombinant Human Fumarase protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher. -
Purity
- > 95 % pure
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Endotoxin Level
- < 1.0 EU per µg of protein (determined by LAL method)
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Application Notes
- Fumarase protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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Storage Comment
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- FH (Fumarate Hydratase (FH))
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Background
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Fumarase (Fumarate hydratase) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid (TCA), or Krebs cycle. This enzyme exists in both a cytosolic form and an N-terminal extended mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase deficiency can lead to progressive encephalopathy, cerebral atrophy and developmental delay and this enzyme also is thought to act as a tumor suppressor. Recombinant Fumarase was expressed in E. coli and was purified by conventional chromatography techniques.
Alternative Names: FH protein, MCUL1 protein, MCL protein, HLRCC protein, LRCC protein, MCUL 1 protein, Fumarate hydratase mitochondrial protein, Fumarate hydratase Fumarase protein, Multiple hereditary cutaneous leiomyomata. -
Molecular Weight
- 50.2 kDa (467 AA)
Target
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