RE1-Silencing Transcription Factor (REST) Peptide
REST
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN936788
Quick Overview for RE1-Silencing Transcription Factor (REST) Peptide (ABIN936788)
Target
REST
(RE1-Silencing Transcription Factor (REST))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- ANMGMALTND MYDLHELSKA ELAAPQLIML ANVALTGEAS GSCCDYLVGE
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of Rest antibody,
Alternative Names: Rest control peptide, Rest antibody Blocking Peptide, Anti-Rest Blocking Peptide, RE1-silencing transcription factor Blocking Peptide, 2610008J04Rik Blocking Peptide, AA407358 Blocking Peptide, MGC150099 Blocking Peptide, NRSF Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- REST (RE1-Silencing Transcription Factor (REST))
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Background
- Rest is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Rest restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Rest mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
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Molecular Weight
- 118 kDa
Target
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