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Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Peptide

PCMT1 Reactivity: Mammalian Host: Synthetic BP, WB, IHC
Catalog No. ABIN936828
  • Target See all PCMT1 products
    PCMT1 (Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1))
    Peptide Type
    Synthetic
    Origin
    Mammalian
    Source
    • 1
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    APYDAIHVGA AAPVVPQALI DQLKPGGRLI LPVGPAGGNQ MLEQYDKLQD
    Characteristics
    A synthetic peptide for use as a blocking control in assays to test for specificity of PCMT1 antibody,
    Alternative Names: PCMT1 control peptide, PCMT1 antibody Blocking Peptide, Anti-PCMT1 Blocking Peptide, Protein-L-Isoaspartate Blocking Peptide, D-Aspartate O-Methyltransferase Blocking Peptide, PCMT1, PCMT-1, PCMT 1, PCMT-1 Blocking Peptide, PCMT 1 Blocking Peptide
  • Application Notes
    Optimal conditions should be determined by the investigator
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
    Buffer
    PBS
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C long term.
  • Target
    PCMT1 (Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1))
    Background
    Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.
    Molecular Weight
    25 kDa
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