Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Peptide
PCMT1
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN936828
Quick Overview for Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Peptide (ABIN936828)
Target
PCMT1
(Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- APYDAIHVGA AAPVVPQALI DQLKPGGRLI LPVGPAGGNQ MLEQYDKLQD
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of PCMT1 antibody,
Alternative Names: PCMT1 control peptide, PCMT1 antibody Blocking Peptide, Anti-PCMT1 Blocking Peptide, Protein-L-Isoaspartate Blocking Peptide, D-Aspartate O-Methyltransferase Blocking Peptide, PCMT1, PCMT-1, PCMT 1, PCMT-1 Blocking Peptide, PCMT 1 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- PCMT1 (Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1))
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Background
- Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.
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Molecular Weight
- 25 kDa
Target
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