Crossover junction endonuclease EME1 (EME1) Peptide
EME1
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN937018
Quick Overview for Crossover junction endonuclease EME1 (EME1) Peptide (ABIN937018)
Target
Crossover junction endonuclease EME1 (EME1)
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- AYPSPQLLVQ AYQQCFSDKE RQNLLADIQV RRGEGVTSTS RRIGPELSRR
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of EME1 antibody,
Alternative Names: EME1 control peptide, EME1 antibody Blocking Peptide, Anti-EME1 Blocking Peptide, Essential Meiotic Endonuclease 1 Homolog 1 Blocking Peptide, FLJ31364 Blocking Peptide, MMS4L Blocking Peptide, EME1, EME-1, EME 1, EME-1 Blocking Peptide, EME 1 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- Crossover junction endonuclease EME1 (EME1)
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Background
- EME1 interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. EME1 may be required in mitosis for the processing of stalled or collapsed replication forks.EME1 and MUS81 form an endonuclease complex that cleaves branched DNA structures, especially those arising during stalled DNA replication.
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Molecular Weight
- 63 kDa
Target
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