Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) Peptide
APBB1
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN937349
Quick Overview for Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) Peptide (ABIN937349)
Target
FE65 (APBB1)
(Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- DGPREHSKSA SLLFGMRNSA ASDEDSSWAT LSQGSPSYGS PEDTDSFWNP
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of Apbb1 antibody,
Alternative Names: Apbb1 control peptide, Apbb1 antibody Blocking Peptide, Anti-Apbb1 Blocking Peptide, amyloid beta, A4 precursor protein-binding, family B, member 1 Blocking Peptide, Fe65 Blocking Peptide, Rir Blocking Peptide, Apbb1, Apbb-1, Apbb 1, Apbb-1 Blocking Peptide, Apbb 1 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
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Background
- Apbb1 is an adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain.Apbb1 plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. Apbb1 may act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1.
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Molecular Weight
- 78 kDa
Target
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