Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) Peptide
VHL
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN937698
Quick Overview for Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) Peptide (ABIN937698)
Target
VHL
(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- EDGGEESGAE ESGPEESGPE ELGAEEEMEA GRPRPVLRSV NSREPSQVIF
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of VHL antibody,
Alternative Names: VHL control peptide, VHL antibody Blocking Peptide, Anti-VHL Blocking Peptide, von Hippel-Lindau tumor suppressor Blocking Peptide, HRCA1 Blocking Peptide, RCA1 Blocking Peptide, VHL1 Blocking Peptide
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Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) peptide
VHL Reactivity: Human, Rat, Mouse, Dog Host: Synthetic BP, Imm
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- VHL (Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
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Background
- Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
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Molecular Weight
- 19 kDa
Target
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