Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) Peptide
EGLN3
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN938515
Quick Overview for Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) Peptide (ABIN938515)
Target
EGLN3
(Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- FWSDRRNPHE VQPSYATRYA MTVWYFDAEE RAEAKKKFRN LTRKTESALT
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of EGLN3 antibody,
Alternative Names: EGLN3 control peptide, EGLN3 antibody Blocking Peptide, Anti-EGLN3 Blocking Peptide, Egl Nine Homolog 3 Blocking Peptide, FLJ21620 Blocking Peptide, HIFPH3 Blocking Peptide, MGC125998 Blocking Peptide, MGC125999 Blocking Peptide, PHD3 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
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Background
- EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
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Molecular Weight
- 27 kDa
Target
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