DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Peptide
DNMT3B
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN938993
Quick Overview for DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Peptide (ABIN938993)
Target
DNMT3B
(DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
-
-
Peptide Type
- Synthetic
-
Sequence
- GTGRLFFEFY HLLNYSRPKE GDDRPFFWMF ENVVAMKVGD KRDISRFLEC
-
Characteristics
-
A synthetic peptide for use as a blocking control in assays to test for specificity of DNMT3 B antibody,
Alternative Names: DNMT3B control peptide, DNMT3B antibody Blocking Peptide, Anti-DNMT3B Blocking Peptide, Dna Blocking Peptide, Cytosine-5-Methyltransferase 3 Beta Blocking Peptide, ICF Blocking Peptide, M.HsaIIIB Blocking Peptide, DNMT3B, DNMTB-3, DNMTB 3, DNMTB-3 Blocking Peptide, DNMTB 3 Blocking Peptide
-
-
-
-
Application Notes
- Optimal conditions should be determined by the investigator
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
-
Buffer
- PBS
-
Handling Advice
- Avoid repeated freeze/thaw cycles.
-
Storage
- -20 °C
-
Storage Comment
- Store at -20 °C long term.
-
-
- DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))
-
Background
- DNMT3B is required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. DNMT3B may preferentially methylate nucleosomal DNA within the nucleosome core region. DNMT3B may function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. DNMT3B seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, DNMT3B is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
-
Molecular Weight
- 86 kDa
Target
-
You are here:
