Smg-8 Homolog, Nonsense Mediated mRNA Decay Factor (SMG8) Peptide
SMG8
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN939088
Quick Overview for Smg-8 Homolog, Nonsense Mediated mRNA Decay Factor (SMG8) Peptide (ABIN939088)
Target
SMG8
(Smg-8 Homolog, Nonsense Mediated mRNA Decay Factor (SMG8))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- HCVHKFHSLP KSGEKPEADR NPPVLYHNSR ARSTGACNCG RKQAPRDDPF
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of C17 orf71 antibody,
Alternative Names: C17ORF71 control peptide, C17ORF71 antibody Blocking Peptide, Anti-C17ORF71 Blocking Peptide, FLJ10587 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- SMG8 (Smg-8 Homolog, Nonsense Mediated mRNA Decay Factor (SMG8))
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Background
- The C17ORF71 protein is a component of the SMG1C complex, a mRNA surveillance complex that recognises and degrades mRNAs containing premature translation termination codons (PTCs) via the nonsense-mediated mRNA decay (NMD). The complex probably acts by associating with ribosomes during tranlation termination on mRNPs. If an exon junction complex (EJC) is located 50-55 or more nucleotides downstream from the termination codon, SMG1 phosphorylates UPF1/RENT1, triggering nonsense-mediated mRNA decay (NMD).
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Molecular Weight
- 110 kDa
Target
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