O6-Methylguanine-DNA-Methyltransferase (MGMT) Peptide
MGMT
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN939556
Quick Overview for O6-Methylguanine-DNA-Methyltransferase (MGMT) Peptide (ABIN939556)
Target
MGMT
(O6-Methylguanine-DNA-Methyltransferase (MGMT))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- ISYQQLAALA GNPKAARAVG GAMRGNPVPI LIPCHRVVCS SGAVGNYSGG
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of MGMT antibody,
Alternative Names: MGMT control peptide, MGMT antibody Blocking Peptide, Anti-MGMT Blocking Peptide, O-6-MethylRNA guanine-Dna Methyltransferase Blocking Peptide -
Purification
- The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))
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Background
- MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA.MGMT repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
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Molecular Weight
- 22 kDa
Target
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