Minichromosome Maintenance Deficient 4 (MCM4) Peptide
MCM4
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN939711
Quick Overview for Minichromosome Maintenance Deficient 4 (MCM4) Peptide (ABIN939711)
Target
MCM4
(Minichromosome Maintenance Deficient 4 (MCM4))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- KEELAEALKK LILSKGKTPA LKYQQLFEDI RGQSDIAITK DMFEEALRAL
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of MCM4 antibody,
Alternative Names: MCM4 control peptide, MCM4 antibody Blocking Peptide, Anti-MCM4 Blocking Peptide, Minichromosome Maintenance Complex Component 4 Blocking Peptide, MCM4, MCM-4, MCM 4, MCM-4 Blocking Peptide, MCM 4 Blocking Peptide -
Purification
- Rabbit Anti-c-Jun (Ab-73) Polyclonal Antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
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Background
- The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRkDaC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
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Molecular Weight
- 95 kDa
Target
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