Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) Peptide
PSMD10
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN939740
Quick Overview for Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) Peptide (ABIN939740)
Target
PSMD10
(Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- KERILADKSL ATRTDQDSRT ALHWACSAGH TEIVEFLLQL GVPVNDKDDA
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of Psmd10 antibody,
Alternative Names: Psmd10 control peptide, Psmd10 antibody Blocking Peptide, Anti-Psmd10 Blocking Peptide, proteasome, prosome, macropain 26S subunit, non-ATPase, 10 Blocking Peptide, AW554874 Blocking Peptide, Psmd10, Psmd-10, Psmd 10, Psmd-10 Blocking Peptide, Psmd 10 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
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Background
- Psmd10 acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly,Psmd10 is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module By similarity.Psmd10 acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression of this gene is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Psmd10 regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4.
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Molecular Weight
- 25 kDa
Target
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