Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) Peptide
PSMD10
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
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- Target See all PSMD10 products
- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
- Peptide Type
- Synthetic
- Origin
- Mammalian
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- KERILADKSL ATRTDQDSRT ALHWACSAGH TEIVEFLLQL GVPVNDKDDA
- Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of Psmd10 antibody,
Alternative Names: Psmd10 control peptide, Psmd10 antibody Blocking Peptide, Anti-Psmd10 Blocking Peptide, proteasome, prosome, macropain 26S subunit, non-ATPase, 10 Blocking Peptide, AW554874 Blocking Peptide, Psmd10, Psmd-10, Psmd 10, Psmd-10 Blocking Peptide, Psmd 10 Blocking Peptide
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- Application Notes
- Optimal conditions should be determined by the investigator
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C long term.
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- Target
- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
- Synonyms
- gankyrin Peptide, zgc:109707 Peptide, dJ889N15.2 Peptide, p28 Peptide, p28(GANK) Peptide, AW554874 Peptide, p28Gank Peptide, proteasome 26S subunit, non-ATPase 10 Peptide, proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Peptide, psmd10 Peptide, PSMD10 Peptide, Psmd10 Peptide
- Background
- Psmd10 acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly,Psmd10 is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module By similarity.Psmd10 acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression of this gene is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Psmd10 regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4.
- Molecular Weight
- 25 kDa
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