alpha-2-Macroglobulin (A2M) (N-Term) Peptide
A2M
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN972683
Quick Overview for alpha-2-Macroglobulin (A2M) (N-Term) Peptide (ABIN972683)
Target
alpha 2 Macroglobulin (A2M)
(alpha-2-Macroglobulin (A2M))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- PVPGHVTVSI CRKYSDASDC HGEDSQAFCE KFSGQLNSHG CFYQQVKTKV
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-A2M Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))
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Background
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Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.
Alias Symbols: CPAMD5, DKFZp779B086, FWP007, S863-7, A2MD
Protein Interaction Partner: ADAM19,ADAMTS1,AMBP,ANXA6,APOE,ATF7IP,B2M,C11orf58,CELA1,CTSB,CTSE,HSPA5,IL10,IL1B,KLK2,KLK3,LCAT,LEP,LRP1,LYZ,MMP2,MYOC,NGF,PAEP,PDGFA,PDGFB,SHBG,TGFBI,STAT3,ADAMTS1,AMBP,ANXA7,APOE,B2M,C11orf58,CDC42,CDK2AP2,CDKN1A,CPB2,GEM,GRB2,H2AFX,HMOX2,HSPA5,IL10,IL4,KLK13,KLK3,LCAT,LEP,LRP1,MMP2,NGF,NUDT21,PAEP,RAP1B,RPP14,SEPT8,SMN1,TGIF1,TK1,TNFRSF14,TSC22D1,TTR,UFD1L
Protein Size: 1474 -
Molecular Weight
- 161 kDa
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Gene ID
- 2
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NCBI Accession
- NM_000014, NP_000005
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UniProt
- P01023
Target
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