Actin, alpha 1, Skeletal Muscle (ACTA1) (N-Term) Peptide
ACTA1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN972856
Quick Overview for Actin, alpha 1, Skeletal Muscle (ACTA1) (N-Term) Peptide (ABIN972856)
Target
Actin (ACTA1)
(Actin, alpha 1, Skeletal Muscle (ACTA1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- GQKDSYVGDE AQSKRGILTL KYPIEHGIIT NWDDMEKIWH HTFYNELRVA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ACTA1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Actin (ACTA1) (Actin, alpha 1, Skeletal Muscle (ACTA1))
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Background
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The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
Alias Symbols: ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3
Protein Interaction Partner: ABL1,ACTA1,ACTR10,ACTR1B,ADSS,AFAP1,AIF1,CCIN,CCT4,CCT5,CFL1,CLIC5,CNN1,CORO2B,COTL1,CTNND1,CTTN,CYFIP1,CYTH1,DLG1,DMD,DNASE1,DNMBP,DTNA,EGFR,EPB41,EPB41L2,EPS8,FGD4,FHOD1,FSCN1,GAS2,GAS7,GC,GSN,HCLS1,HIP1R,IQGAP1,ITGA2,ITPKA,JUB,KIF23,KLHL20,LASP1,MACF1,
Protein Size: 377 -
Molecular Weight
- 42 kDa
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Gene ID
- 58
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NCBI Accession
- NM_001100, NP_001091
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UniProt
- P68133
Target
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