Activin A Receptor, Type IIB (ACVR2B) (Middle Region) Peptide
ACVR2B
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN972887
$160.46
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100 μg
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Quick Overview for Activin A Receptor, Type IIB (ACVR2B) (Middle Region) Peptide (ABIN972887)
Target
ACVR2B
(Activin A Receptor, Type IIB (ACVR2B))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- KSKNVLLKSD LTAVLADFGL AVRFEPGKPP GDTHGQVGTR RYMAPEVLEG
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ACVR2B Antibody(ARP45042_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
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Background
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Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B is activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
Alias Symbols: ACTRIIB, ActR-IIB, MGC116908, HTX4
Protein Interaction Partner: ACVR1B,BMP2,BMP7,GDF11,GDF5,IGSF1,INHBA,INHBB,INHBC,MSTN,SNX1,SNX2,SNX6,SYNJ2BP,TGFBRAP1,ACVR1B,BMP6,BMP7,ENG,GDF5,INHBA,INHBB,MSTN,SNX1,SNX2,SNX6,SYNJ2BP
Protein Size: 512 -
Molecular Weight
- 58 kDa
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Gene ID
- 93
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NCBI Accession
- NM_001106, NP_001097
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UniProt
- Q13705
Target
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