Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (N-Term) Peptide
ADRBK1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN972965
Quick Overview for Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (N-Term) Peptide (ABIN972965)
Target
GRK2 (ADRBK1)
(Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- PEPSIRSVMQ KYLEDRGEVT FEKIFSQKLG YLLFRDFCLN HLEEARPLVE
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ADRBK1 Antibody(ARP51965_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
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Background
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The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
Alias Symbols: BARK1, BETA-ARK1, FLJ16718, GRK2
Protein Interaction Partner: PEBP1,ADRA2A,AGTR1,AKAP12,ARRB1,BDKRB2,CAPN2,CAV1,CCR4,CCR5,EGF,EGFR,FPR1,FSHR,GIT1,GIT2,GNAQ,GRM1,MAPK3,MC4R,MDM2,NCS1,OPRD1,PDC,PDCL,PDE6G,PEBP1,PIK3CG,PRKACA,PRKCA,PRKCB,PRKCD,PRKCG,RCVRN,RHO,RPLP2,SNCA,SRC,TPM2,ADRB2,AGTR1,CAV1,CCR4,EDNRB,FSHR,GIT1,GI
Protein Size: 689 -
Molecular Weight
- 79 kDa
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Gene ID
- 156
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NCBI Accession
- NM_001619, NP_001610
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UniProt
- P25098
Target
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