A Kinase (PRKA) Anchor Protein 5 (AKAP5) (Middle Region) Peptide
AKAP5
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN973055
Quick Overview for A Kinase (PRKA) Anchor Protein 5 (AKAP5) (Middle Region) Peptide (ABIN973055)
Target
AKAP5
(A Kinase (PRKA) Anchor Protein 5 (AKAP5))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-AKAP5 antibody (Catalog #: ARP36322_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- AKAP5 (A Kinase (PRKA) Anchor Protein 5 (AKAP5))
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Target Type
- Viral Protein
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Background
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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP5 is a member of the AKAP family. It binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AKAP75, AKAP79, H21
Protein Interaction Partner: ADRB2,CALM1,DLG1,DLG4,GABRB1,GABRB3,IQGAP1,KCNJ2,PPP3CA,PRKAR2A,PRKAR2B,PRKCA,RET,Dlg1,Dlg4,GABRB3,Gria1,Grin2b,IQGAP1,PPP3CA,PRKAR2A,PRKAR2B
Protein Size: 427 -
Molecular Weight
- 47 kDa
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Gene ID
- 9495
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NCBI Accession
- NM_004857, NP_004848
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UniProt
- P24588
Target
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