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AKT1 Substrate 1 (Proline-Rich) (AKT1S1) Peptide

AKT1S1 Reactivity: Human Host: Synthetic BP, WB

Catalog No. ABIN973083

Quick Overview for AKT1 Substrate 1 (Proline-Rich) (AKT1S1) Peptide (ABIN973083)

Target

PRAS40 (AKT1S1) (AKT1 Substrate 1 (Proline-Rich) (AKT1S1))

Origin

Human

Source

Synthetic

Application

Blocking Peptide (BP), Western Blotting (WB)

Characteristics

This is a synthetic peptide designed for use in combination with anti-AKT1S1 antibody (Catalog #: ARP48061_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.

Purification

Purified
AKT1 Substrate 1 (Proline-Rich) (AKT1S1) peptide
AKT1S1 Reactivity: Mammalian Host: Synthetic BP, WB, IHC

AKT1 Substrate 1 (Proline-Rich) (AKT1S1) (C-Term) peptide
AKT1S1 Reactivity: Human Host: Synthetic BP, BI Sodium azide

AKT1 Substrate 1 (Proline-Rich) (AKT1S1) (Middle Region) peptide
AKT1S1 Reactivity: Human, Rat Host: Synthetic BP, WB

AKT1 Substrate 1 (Proline-Rich) (AKT1S1) peptide
AKT1S1 Host: Synthetic BP, WB, ICo, IDe

AKT1 Substrate 1 (Proline-Rich) (AKT1S1) peptide
AKT1S1 Reactivity: Human, Rat, Cow, Mouse Host: Synthetic BP

AKT1 Substrate 1 (Proline-Rich) (AKT1S1) (pSer246) peptide
AKT1S1 Reactivity: Human, Rat, Cow, Mouse Host: Synthetic BP

Application Notes

Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions

For Research Use only
Format

Lyophilized

Reconstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Concentration

1 mg/mL

Buffer

Final peptide concentration is 1 mg/mL in PBS.

Handling Advice

Avoid repeated freeze-thaw cycles.

Storage

-20 °C

Storage Comment

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

PRAS40 (AKT1S1) (AKT1 Substrate 1 (Proline-Rich) (AKT1S1))

Background

AKT1S1 may play an important role in phosphatidylinositol 3-kinase (PI3K)-AKT1 survival signaling. It is the substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. AKT1S1 may also play a role in nerve growth factor-mediated neuroprotection.AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM].

Alias Symbols: Lobe, MGC2865, PRAS40

Protein Interaction Partner: AKT1,AKT2,EIF6,MTOR,TCEA2,YWHAG,EIF6,TCEA2

Protein Size: 256

Molecular Weight

27 kDa

Gene ID

84335

NCBI Accession

NM_032375, NP_115751

UniProt

Q96B36

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