Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (N-Term) Peptide
APEX1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN973300
Quick Overview for Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (N-Term) Peptide (ABIN973300)
Target
APEX1
(Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- MPKRGKKGAV AEDGDELRTE PEAKKSKTAA KKNDKEAAGE GPALYEDPPD
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-APEX1 Antibody(ARP58027_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
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Background
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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene, all encode the same protein.
Alias Symbols: APE, APE1, APEN, APEX, APX, HAP1, REF-1, REF1
Protein Interaction Partner: CDKN1A,MUTYH,TP53,ANP32A,ANP32C,APEX1,CSNK2A1,DCTN1,EP300,FEN1,GZMA,HDAC1,HIF1A,HMGB2,HNRNPL,HSPA1A,MUTYH,NME1,NXF2,PCNA,POLB,SET,TP53,TXN,UBE2I,XRCC1,XRCC6,ANP32A,FEN1,HIF1A,HNRNPL,MUTYH,PCNA,SET,TP53,XRCC1,XRCC5
Protein Size: 318 -
Molecular Weight
- 35 kDa
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Gene ID
- 328
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NCBI Accession
- NM_001641, NP_001632
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UniProt
- P27695
Target
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