Amyloid beta (A4) Precursor Protein (APP) (Middle Region) Peptide
APP
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN973340
Quick Overview for Amyloid beta (A4) Precursor Protein (APP) (Middle Region) Peptide (ABIN973340)
Target
APP
(Amyloid beta (A4) Precursor Protein (APP))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-APP antibody (Catalog #: ARP33075_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- APP (Amyloid beta (A4) Precursor Protein (APP))
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Background
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APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Alias Symbols: AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, PN-II
Protein Interaction Partner: NAE1,TGFB1,TGFB2,APBA1,APP,HTRA2,PSEN1,PSEN1,PSEN1,PSEN2,APBA1,MAPK8IP1,PSEN1,PSEN1,ABL1,ACHE,APBA1,APBA2,APBA3,APBB1,APBB2,APBB3,APOE,APPBP2,BACE1,BACE2,BCAP31,BGN,BLMH,CALR,CASP3,CASP4,CASP6,CASP8,CAV1,CDK5,CHRNA7,CLU,COL1A2,COL25A1,COL4A1,COL4A2,COL4A3,COL4A5,COL4A6,CRYAB,CTSD,DAB1,EPB41,F12,FBLN1,FLOT1,GAPDH,GPC1,GRB2,GSK3B,GSN,HADHB,HMOX2,HSD17B10,HSPG2,HTRA2,IDE,ITM2B,KAT5,KLC1,KNG1,LAMA1,LDLRAP1,LRP1,LRP1B,MAPK8IP1,MAPK8IP2,NAE1,NCSTN,NECAB3,NF1,NID1,NUMB,NUMBL,PIN1,PPID,PRSS2,PRSS3,PSEN1,PSEN2,SERPINA3,SHC1,SHC3,SNCA,SNCB,SPON1,TGFB1,TGFB2,TM2D1,TP53BP2,ACHE,APBA1,APBA2,APBA3,APBB1,APBB2,APBB3,APPBP2,Apbb1,Apbb1,BGN,BLMH,CALR,CAV1,CLSTN1,COL25A1,DAB1,DAB2,FBLN1,GSN,HGS,HSD17B10,KLC1,NAE1,NCSTN,SHC1,SNCA,SNCB
Protein Size: 770 -
Molecular Weight
- 85 kDa
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Gene ID
- 351
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NCBI Accession
- NM_000484, NP_000475
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UniProt
- P05067
Target
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