B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (N-Term) Peptide
BCL11A
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN973775
Quick Overview for B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (N-Term) Peptide (ABIN973775)
Target
BCL11A
(B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-BCL11A antibody (Catalog #: ARP39322_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))
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Background
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BCL11A Is a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression.This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
Alias Symbols: BCL11A-L, BCL11A-S, BCL11A-XL, CTIP1, EVI9, FLJ10173, FLJ34997, HBFQTL5, KIAA1809, ZNF856
Protein Interaction Partner: NR2F1,NR2F2,NR2F1
Protein Size: 835 -
Molecular Weight
- 91 kDa
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Gene ID
- 53335
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NCBI Accession
- NM_022893, NP_075044
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UniProt
- Q9H165
Target
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